医学论文发表：原花青素对小鼠运动性疲劳及抗氧化能力的影响 |
| 时间：2019-02-26 09:43:36 来源：[!--befrom--] 作者：[!--writer--] |
摘要：为研究原花青素对小鼠运动性疲劳及抗氧化能力的影响，2018年10-2018年12月选取5周龄健康雄性小鼠45只，随机分为3组（安静对照组、单纯运动组、实验组），进行8周游泳训练。小鼠运动结束后，通过麻醉处死，采集血液组织，检测血清各指标。结果表明：服用原花青素后，实验组（13.6±1.1）min力竭时间比安静对照组（9.1±0.6）min和单纯运动组（8.9±0.8）min相比要长（t=7.362,6.231，P＜0.05）；实验结束后对小鼠血液进行检测，研究结果发现灌胃原花青素的试验组小鼠血清中MDA（6.15±0.85）nmol/ml、ＢＵＮ（8.11±0.62）nmol/ml含量明显低于单纯运动组(7.24±1.03，9.86±0.53)nmol/ml，（t=7.642,6.571，P＜0.05）说明原花青素具有很强的降低运行疲劳小鼠MDA、ＢＵＮ含量的作用；试验组小鼠的血清SOD（36.74±0.57）U/ml、GSH-PX（41.71±1.38）U/ml、T-AOC（0.73±0.16）U/ml活性明显高于安静对照组（34.41±1.91，36.97±0.79，0.48±0.12）U/ml，（t=4.712,5.541，6.971，P＜0.05），且与单纯运动组SOD（31.44±1.47）U/ml、GSH-PX（32.01±0.81）U/ml、T-AOC（0.25±0.06）U/ml相比，试验组数据均活性显著升高（t=7.642,5.481，6.851，P＜0.01。说明原花青素能提高小鼠抗运动性疲劳及抗氧化能力，对于后期原花青素应用到人体具有重要价值。
关键词：原花青素;运动性疲劳；抗氧化
Effects of procyanidins on exercise-induced fatigue and antioxidant capacity in mice
Zang shouxiang
College of Physical Education, Xinjiang Normal University, Urumqi, Xinjiang 830054
ABSTRACT:To study the effects of proanthocyanidins on exercise-induced fatigue and antioxidant capacity in mice, 45 healthy male mice aged 5 weeks were selected from October 2018 to December 2018 and randomly divided into three groups (quiet control group, simple exercise group and experimental group) for 8 weeks swimming training. After the mice were executed under anesthesia, blood tissues were collected and serum indexes were detected. The results showed that after taking proanthocyanidins, the exhaustion time of the experimental group (13.6±1.1) min was longer than that of the quiet control group (9.1±0.6) min and the simple exercise group(8.9±0.8)min (t=7.362,6.231,P<0.05).After the experiment, the blood of mice was tested. The results showed that the serum levels of MDA (6.15±0.85) nmol/ml and BUN (8.11±0.62) nmol/ml in the experimental group were significantly lower than those in the simple exercise group (7.24±1.03, 9.86±0.53) nmol/ml, (t=7.642, 6.571, P<0.05). It indicated that proanthocyanidins had a strong effect on reducing the levels of MDA and BUN in mice with running fatigue. Effect; The serum SOD (36.74 ±0.57) U/ml, GSH-PX (41.71±1.38) U/ml, T-AOC (0.73±0.16) U/ml activities in the experimental group were significantly higher than those in the quiet control group (34.41±1.91,36.97±0.79,0.48±0.12) U/ml (t=4.712,5.541,6.971,P<0.05)., andCompared with SOD (31.44±1.47) U/ml, GSH-PX (32.01±0.81) U/ml and T-AOC (0.25±0.06) U/ml in the exercise group, the activity of anthocyanins in the test group was significantly increased(t=7.642,5.481,6.851,P<0.01).Anthocyanins can improve the anti-exercise fatigue and anti-oxidation ability of mice, which is of great value for the later application of proanthocyanidins to human body.
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